Fluoroquinolone Prophylaxis Reduces Intensive Care Unit Admission and <i>Clostridioides difficile</i> Rates in Acute Myeloid Leukemia Induction Chemotherapy

In this cohort, FQ prophylaxis did not significantly reduce bloodstream infections but was associated with fewer ICU admissions and lower rates of <i>C. difficile</i> infection. These findings further support the use of FQ prophylaxis with minimal concern for exacerbation of <i>C. difficile</i> rates. It further highlights ongoing risk from enteric translocation despite prophylaxis.

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Publication Details

Journal
eJHaem
Published
2026-02-01
DOI
https://doi.org/10.1002/jha2.70225
Primary Topic
Neutropenia and Cancer Infections
Type
article
Field-Weighted Citation Impact
0.00
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article

Fluoroquinolone Prophylaxis Reduces Intensive Care Unit Admission and Clostridioides difficile Rates in Acute Myeloid Leukemia Induction Chemotherapy

Anvay Shah, Sujith Abbagoni, Mark Dalgetty, Vamsi Kota et al.
eJHaem
Neutropenia and Cancer Infections
article

Fluoroquinolone Prophylaxis Reduces Intensive Care Unit Admission and Clostridioides difficile Rates in Acute Myeloid Leukemia Induction Chemotherapy

Anvay Shah, Sujith Abbagoni, Mark Dalgetty, Vamsi Kota, Mohammad Mian, Faizan Boghani, Andrea Clarke, Charles Weeks, J Cortes, Lydia Delay, Anand Jillella, Matthew Gold, Heeju Lim, Ozal Ismayilov, Chandini Kannan, Priyanka Menon
article en

Abstract

In this cohort, FQ prophylaxis did not significantly reduce bloodstream infections but was associated with fewer ICU admissions and lower rates of <i>C. difficile</i> infection. These findings further support the use of FQ prophylaxis with minimal concern for exacerbation of <i>C. difficile</i> rates. It further highlights ongoing risk from enteric translocation despite prophylaxis.

eJHaemVol. 7(1)
Augusta University (US), National Cancer Center of Georgia (GE)
Good health and well-being
Openalex Percentile: Top 55%
Neutropenia and Cancer Infections
DOIOpen Access PDFOpenAlex
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Fluoroquinolone Prophylaxis Reduces Intensive Care Unit Admission and <i>Clostridioides difficile</i> Rates in Acute Myeloid Leukemia Induction Chemotherapy — Anvay Shah, Sujith Abbagoni, et al. · eJHaem (2026) | TGRS Research Map | TGRS