Plasma Biomarkers of Senescence in Cholestatic Liver Disease: A Signature of Risk Stratification and Progression
This is the first study to define a plasma SASP biomarker signature associated with cholestatic liver disease. These analytes track disease stage and represent both mechanistic indicators and potential clinical trial endpoints.
Authors
- Ahmad H. Ali (ORCID: https://orcid.org/0000-0001-8553-7744)
- Pamela Tietz Bogert
- Xiwei Chen (ORCID: https://orcid.org/0000-0003-1868-8387)
- David B. Allison (ORCID: https://orcid.org/0000-0003-3566-9399)
- Humza M. Ashraf (ORCID: https://orcid.org/0000-0001-7042-312X)
- Jair Machado Espindola Netto
- Olivia Morgenthaler (ORCID: https://orcid.org/0000-0003-1217-0309)
- Tamara Tchkonia
- Stephanie Dickinson
- Konstantinos N. Lazaridis
- Gregory J. Gores
- Nicholas LaRusso
- Steven P. O'Hara
- James L. Kirkland
Institutions
- Cedars-Sinai Medical Center (US)
- Mayo Clinic (US)
- WinnMed (US)
- Indiana University Bloomington (US)
- Mayo Clinic in Florida (US)
- University of Missouri (US)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1111/jgh.70279
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00