<scp>KCC2</scp> Dysfunction Mediated by Microglial <scp>BDNF</scp> / <scp>TrkB</scp> Signaling Exacerbates Early Post‐Stroke Seizure Susceptibility
Our findings identify microglia-derived BDNF/TrkB signaling as a critical upstream pathway mediating KCC2 dysfunction in early post-stroke seizure. Targeting this axis by inhibiting microglial activation, blocking TrkB, or directly enhancing KCC2 function with activators like CLP290 represents a promising therapeutic strategy for stroke-related epilepsy.
Authors
- Jiangning Yu (ORCID: https://orcid.org/0000-0002-0592-7409)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-3208-9073)
- Kehua Chen
- Zhigang Yang (ORCID: https://orcid.org/0000-0002-6278-3130)
- Jingyi Cai
- Yulong Wang (ORCID: https://orcid.org/0000-0002-0514-1131)
- Mohan Yu
- Li Wan
- Guoxiang Wang
- Yun Wang
- Xu Liu
- Benjamin H. Wang
Institutions
- Fudan University (CN)
- Integrated Chinese Medicine (China) (HK)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70795
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00