Low maternal folic acid during pregnancy exacerbates ectopic fat accumulation in the liver and muscle of male offspring
Maternal FA status plays a critical role in regulating male offspring metabolic health. Maintaining adequate maternal plasma FA levels, rather than focusing solely on dietary intake, may be essential for preventing ectopic fat accumulation in the next generation.
Authors
- Eijiro Jimi (ORCID: https://orcid.org/0000-0003-3616-5299)
- Atsushi Yasukochi
- Kento MINAMI
- Tomoyo Kawakubo‐Yasukochi (ORCID: https://orcid.org/0000-0002-6483-3074)
- Ena Yano
- Mya Thway Tint (ORCID: https://orcid.org/0000-0002-9548-7186)
- Ichiro Takahashi (ORCID: https://orcid.org/0000-0002-3218-5017)
- Shohei Yoshimoto (ORCID: https://orcid.org/0000-0002-3195-2448)
- Soi Kimura
- Navin Michael
- Jun Shi Lai
- Sendhil S. Velan
- Keita Maki
- Ayano Ogura
- Karen Tan
- Suresh Anand Sadananthan
- Masato Hirata
- Koji Kinoshita
- Yi-Chen Lo
- Yoshikazu Hayashi
- Johan G. Eriksson
- Ayaka Saeki
- Fabian Yap
Institutions
- Agency for Science, Technology and Research (SG)
- Kyushu University (JP)
- National Environment Agency (SG)
- National University of Singapore (SG)
- National Taiwan University (TW)
- Kyushu Dental University (JP)
- Kyushu University Hospital (JP)
- Singapore Institute for Clinical Sciences (SG)
- KK Women's and Children's Hospital (SG)
- Fukuoka Dental College (JP)
Publication Details
- Journal
- Diabetes Research and Clinical Practice
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.diabres.2026.113161
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Daiichi Sankyo Foundation of Life Science
- Japan Society for the Promotion of Science
- Daiichi Sankyo Europe