Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches
CKM stage was significantly associated with MASLD prevalence, advanced liver fibrosis, and cirrhosis. Machine learning interpretation highlighted adiposity, glycemic control, and lipid metabolism as the principal contributors, suggesting that these CKM-related metabolic domains may contribute to MASLD and fibrotic burden.
Authors
- Yijie Zheng (ORCID: https://orcid.org/0000-0002-6513-1584)
- Jinghai Song (ORCID: https://orcid.org/0000-0002-7101-8000)
- Shiqi Guo
- Ting Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s40001-026-04037-0
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00