Evaluation of the efficacy and tolerability of bevacizumab-based treatments in recurrent primary brain tumors: a multicenter real-world Turkish Oncology Group (TOG) study
In this large real-world cohort, bevacizumab-based therapy achieved meaningful disease control and survival in recurrent primary brain tumors. An irinotecan-bevacizumab regimen administered every 14 days was associated with superior OS at the expense of increased but manageable chemotherapy-related toxicity, supporting its use in appropriately selected patients.
Authors
- Selver Işık (ORCID: https://orcid.org/0000-0002-2726-1740)
- Fatih Teker (ORCID: https://orcid.org/0000-0003-4693-6587)
- Seda Kahraman (ORCID: https://orcid.org/0000-0002-5328-6554)
- Necla Demir (ORCID: https://orcid.org/0000-0003-0927-6962)
- Şener CİHAN
- Kayhan Ertürk (ORCID: https://orcid.org/0000-0001-5804-6800)
- Meral Günaldı (ORCID: https://orcid.org/0000-0002-5496-9824)
- Ahmet Gülmez (ORCID: https://orcid.org/0000-0002-3353-344X)
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Derya Demirtas Esmer (ORCID: https://orcid.org/0000-0001-7871-9566)
- Fatma Paksoy Türköz
- Asude Aksoy (ORCID: https://orcid.org/0000-0002-5609-9658)
- Gökhan Karakaya (ORCID: https://orcid.org/0000-0002-7970-307X)
- Esra Zeynelgil (ORCID: https://orcid.org/0000-0001-7200-9440)
- Hacı Mehmet Türk (ORCID: https://orcid.org/0000-0003-2206-8148)
- Melek Karakurt Eryılmaz (ORCID: https://orcid.org/0000-0003-2597-5931)
- Engin Kut
- Serdar Turhal
- Eda Çalışkan Yıldırım
- Ozkan Alan
- Özlem Özkul
- Özgecan Dülgar
- Leyla Özer
- Feride Yılmaz
- Sema Türker
- Emir Çelik
- Nilay Şengül
- Şaban Seçmeler
- Zehra Sucuoğlu İşleyen
- M. Mustafa Atcı
- Fatih Karataş
Institutions
- Bahçeşehir University (TR)
- Anadolu University (TR)
- Karabük University (TR)
- Dokuz Eylül University (TR)
- Nicosia General Hospital (CY)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Istanbul Medipol University (TR)
- Memorial Ankara Hospital (TR)
- Necmettin Erbakan University (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Memorial Sisli Hospital (TR)
- Istanbul University-Cerrahpaşa (TR)
- Samsun University (TR)
- Botkin Hospital (RU)
- Istinye University (TR)
- Istanbul Eye Hospital (TR)
- Ankara Yıldırım Beyazıt University (TR)
- Liv Hospital (TR)
- Acıbadem Adana Hospital (TR)
- Antalya IVF (TR)
- İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi (TR)
- Maltepe University (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Istanbul University (TR)
- Marmara University (TR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s12885-026-15725-9
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00