Human-induced pluripotent stem cell derived exosomal miR-103a-3p accelerate urethral injury recovery by promoting angiogenesis via TGFBR3/VEGF/FAK axis
This study indicated that hiPSC-Exo played a crucial role in promoting angiogenesis to accelerate urethral injury repair through the action of miR-103a-3p in exosome on the TGFBR3/VEGF/FAK signaling pathway in endothelial cells. This provides a new treatment strategy for hiPSC-Exo in the clinical treatment of urethral injury healing and elucidates its unique mechanism of action.
Authors
- Qingsong Zou
- Jipeng Wang (ORCID: https://orcid.org/0000-0002-3240-7863)
- Guixin Ding (ORCID: https://orcid.org/0009-0009-7215-3261)
- Yongwei Li (ORCID: https://orcid.org/0000-0002-1731-2591)
- Dongxu Zhang (ORCID: https://orcid.org/0000-0003-3649-9686)
- Yifan Chi (ORCID: https://orcid.org/0000-0001-9878-4736)
- H L Liu
- Jitao Wu
- Fengze Sun
Institutions
- Qingdao University (CN)
- Yuhuangding Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s13287-026-04939-0
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00