A Lesion-adaptive Segmentation Approach for Tumor Delineation on FDG PET/CT in Diffuse Large B-cell Lymphoma Patients

A straightforward decision-rule approach using SUVpeak and SUVbg successfully selects the preferred method for individual DLBCL lesions across treatment phases and matches ML performance with greater simplicity and clinical applicability. Although supervision remains necessary, this approach helps address the current gap in segmentation methodology for interim and EoT PET, where SUV4.0 may not always be appropriate.

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Publication Details

Journal
European Journal of Nuclear Medicine and Molecular Imaging
Published
2026-02-14
DOI
https://doi.org/10.1007/s00259-026-07768-8
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

A Lesion-adaptive Segmentation Approach for Tumor Delineation on FDG PET/CT in Diffuse Large B-cell Lymphoma Patients

Jakoba J. Eertink, Daniëlle M. E. van Assema, P. Lugtenburg, Gerben J. C. Zwezerijnen et al.
European Journal of Nuclear Medicine and Molecular Imaging
Lymphoma Diagnosis and Treatment
article

A Lesion-adaptive Segmentation Approach for Tumor Delineation on FDG PET/CT in Diffuse Large B-cell Lymphoma Patients

Jakoba J. Eertink, Daniëlle M. E. van Assema, P. Lugtenburg, Gerben J. C. Zwezerijnen, Martijn W. Heymans, Michael D. A. van Elk, Yvonne W. S. Jauw, Ronald Boellaard, Otto S. Hoekstra, Patricia C. Spa, Sanne E. Wiegers, Josée M. Zijlstra
article en

Abstract

A straightforward decision-rule approach using SUVpeak and SUVbg successfully selects the preferred method for individual DLBCL lesions across treatment phases and matches ML performance with greater simplicity and clinical applicability. Although supervision remains necessary, this approach helps address the current gap in segmentation methodology for interim and EoT PET, where SUV4.0 may not always be appropriate.

European Journal of Nuclear Medicine and Molecular Imaging
Dutch Cancer Society (NL), Northwest Hospital (US), GGD Amsterdam (NL), Erasmus MC Cancer Institute (NL), Medisch Centrum Alkmaar (NL), Cancer Center Amsterdam (NL), Vrije Universiteit Amsterdam (NL)
Peace, Justice and strong institutions
Openalex Percentile: Top 56%
Lymphoma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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A Lesion-adaptive Segmentation Approach for Tumor Delineation on FDG PET/CT in Diffuse Large B-cell Lymphoma Patients — Jakoba J. Eertink, Daniëlle M. E. van Assema, et al. · European Journal of Nuclear Medicine and Molecular Imaging (2026) | TGRS Research Map | TGRS