Normal tissue complication probability models for gastrointestinal toxicity after adjuvant (chemo)radiotherapy for cervical cancer in the PARCER trial
NTCP models for acute and late diarrhea and persistent GI toxicity after postoperative radiotherapy for cervical cancer included bowel V30Gy and V40Gy. Furthermore, 3DCRT and more extensive surgery increased risks. Further studies should explore additional variables to improve model performance, reach consensus on bowel delineation methods, and validate models externally.
Authors
- A. Corbeau
- Sofia Spampinato (ORCID: https://orcid.org/0000-0002-1953-7313)
- Mayuri Charnalia (ORCID: https://orcid.org/0000-0002-0013-0396)
- R. Engineer
- Jeevanshu Jain
- Sadhana Kannan
- Subhajit Panda
- Remi R.A. Nout
- Sudeep Gupta
- Ankita Gupta
- Prachi Mittal
- Jaya Ghosh
- Nilesh Ranjan
- Stephanie de Boer
- Prachi Sawant
- Tapas Dora
- Supriya Chopra
- Mischa Hoogeman
Institutions
- Homi Bhabha National Institute (IN)
- Bhabha Hospital (IN)
- Leiden University Medical Center (NL)
- Tata Memorial Hospital (IN)
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.radonc.2026.111444
- Citations
- 1
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 41.10
Funders
- Varian Medical Systems
- Siemens Healthineers