Patlak-PBNT: a simple population-based Patlak model to generate [68Ga]Ga-PSMA-11 Ki parametric images for shortened total-body PET scan
The proposed Patlak-PBNT model reduces the dependency on a complete input function, thereby avoiding the need for long-duration PET scans typically required to obtain a full input function. When utilizing dynamic PET images of identical scan durations (20-60 min post-injection), the K<sub>i</sub> images generated by Patlak-PBNT and traditional Patlak are essentially identical. Furthermore, even when the scan duration is further reduced, the Patlak-PBNT method is capable of quantifying 20 minute dynamic [<sup>68</sup>Ga]Ga-PSMA-11 total-body PET images.
Authors
- Wei Gu (ORCID: https://orcid.org/0000-0002-0302-058X)
- Shiming XU
- Wentong Yang
- Yun Zhou (ORCID: https://orcid.org/0000-0001-8635-4675)
- Junbo Ge
- Lianghua Li
- Weijun Wei
- Gongning Luo
- Gang Huang
- Jianjun Liu
Institutions
- University of Shanghai for Science and Technology (CN)
- Harbin Institute of Technology (CN)
- Renji Hospital (CN)
- ShanghaiTech University (CN)
- United Imaging Healthcare (China) (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s40658-026-00840-0
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00