The impact of predator stress on electroshock seizure threshold: insights into GABAergic, glutamatergic, and serotonergic pathways in mice
This study shows that predator stress is associated with increased seizure susceptibility and with downregulation of hippocampal GABAAα1R and 5-HT1AR expression, together with enhanced NF-κB activation and reduced ERK signaling. Pharmacological modulation of GABAergic, glutamatergic, and serotonergic pathways reversed the stress-induced reduction in seizure threshold in this model, suggesting that these systems may contribute to stress-related seizure susceptibility.
Authors
- R Mohammad Jafari (ORCID: https://orcid.org/0009-0001-9561-0965)
- Ali Vafaei (ORCID: https://orcid.org/0000-0001-5747-1792)
- Amirhossein Shahsavand (ORCID: https://orcid.org/0009-0000-9057-1680)
- Ahmad Reza Dehpour
- Hamed Shafaroodi
- Mehdi Ghasemi
- Mohammad Amin Kharaghani
Institutions
- Lahey Hospital and Medical Center (US)
- Harvard University (US)
- Lahey Medical Center (US)
- Dana-Farber Cancer Institute (US)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s12993-026-00321-5
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00