A novel microprotein MUCP1 promotes colorectal cancer metabolic reprogramming by regulating mitochondrial succinate transport
This study identifies MUCP1 as a novel lncRNA-encoded microprotein that maintains metabolic homeostasis in CRC by coupling mitochondrial succinate transport to histone methylation. MUCP1 might be a promising metabolic vulnerability and therapeutic target in CRC.
Authors
- Shangshang Hu (ORCID: https://orcid.org/0009-0009-3828-9907)
- Shukui Wang (ORCID: https://orcid.org/0000-0001-6972-2587)
- Mu Xu (ORCID: https://orcid.org/0000-0002-5081-8842)
- Linpeng Zhou
- Xi Liu (ORCID: https://orcid.org/0000-0002-6741-4094)
- Han Sun (ORCID: https://orcid.org/0000-0002-7850-9574)
- Xiaolan Gu (ORCID: https://orcid.org/0009-0005-4227-6894)
- Yuqin Pan (ORCID: https://orcid.org/0000-0003-4028-6835)
- Junjie NIE
- Tao Xu
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.neo.2026.101287
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 24.82