Choline attenuates bilirubin induced effects on tyrosine phosphorylation and distribution in lipid rafts of L1 cell adhesion molecule in vivo
This article found that choline is an intervention for the neurotoxic effects of bilirubin on the choline-restricted developing brain in vivo. This article provides clear evidence toward establishing one intervention for bilirubin neurotoxicity, where little is understood. This article paves the way for future investigation into the mechanism of the ameliorative effect of choline on bilirubin neurotoxicity.
Authors
- Cynthia F. Bearer (ORCID: https://orcid.org/0000-0003-4809-2250)
- Mrinaj Janampalli
- Ningfeng Tang
- Min He
- Carter Joyce
- Spencer T. Kitchen
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Rainbow Babies & Children's Hospital (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1038/s41390-026-04788-w
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health