Choline attenuates bilirubin induced effects on tyrosine phosphorylation and distribution in lipid rafts of L1 cell adhesion molecule in vivo

This article found that choline is an intervention for the neurotoxic effects of bilirubin on the choline-restricted developing brain in vivo. This article provides clear evidence toward establishing one intervention for bilirubin neurotoxicity, where little is understood. This article paves the way for future investigation into the mechanism of the ameliorative effect of choline on bilirubin neurotoxicity.

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Publication Details

Journal
Pediatric Research
Published
2026-02-14
DOI
https://doi.org/10.1038/s41390-026-04788-w
Primary Topic
Neonatal Health and Biochemistry
Type
article
Field-Weighted Citation Impact
0.00

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article

Choline attenuates bilirubin induced effects on tyrosine phosphorylation and distribution in lipid rafts of L1 cell adhesion molecule in vivo

Cynthia F. Bearer, Mrinaj Janampalli, Ningfeng Tang, Min He et al.
Pediatric Research
Neonatal Health and Biochemistry
article

Choline attenuates bilirubin induced effects on tyrosine phosphorylation and distribution in lipid rafts of L1 cell adhesion molecule in vivo

Cynthia F. Bearer, Mrinaj Janampalli, Ningfeng Tang, Min He, Carter Joyce, Spencer T. Kitchen
article en

Abstract

This article found that choline is an intervention for the neurotoxic effects of bilirubin on the choline-restricted developing brain in vivo. This article provides clear evidence toward establishing one intervention for bilirubin neurotoxicity, where little is understood. This article paves the way for future investigation into the mechanism of the ameliorative effect of choline on bilirubin neurotoxicity.

Pediatric Research
University of Maryland, Baltimore (US), Johns Hopkins University (US), Johns Hopkins Medicine (US), Rainbow Babies & Children's Hospital (US), University School (US), Case Western Reserve University (US)
National Institutes of Health
Openalex Percentile: Top 54%
Neonatal Health and Biochemistry
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