Cirrhosis of Liver in Patients With Dyskeratosis Congenita: A Report of Two Cases

Dyskeratosis congenita (DC) is a genetic disorder characterized by multisystem involvement. The most commonly affected systems are the mucocutaneous, bone marrow, and lungs. Though rare, chronic liver disease (CLD) has increasingly been reported to be associated with DC. The hepatic involvement can range from asymptomatic transaminasemia to end-stage liver disease. In this series, we present two cases of adult male patients with DC and decompensated CLD.

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Journal
Clinical Case Reports
Published
2026-02-01
DOI
https://doi.org/10.1002/ccr3.72044
Primary Topic
Telomeres, Telomerase, and Senescence
Type
article
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article

Cirrhosis of Liver in Patients With Dyskeratosis Congenita: A Report of Two Cases

Bikash Poudel, Abhishek Pandit, Mukesh Kumar Ranjan, Suraj Subedi et al.
Clinical Case Reports
Telomeres, Telomerase, and Senescence
article

Cirrhosis of Liver in Patients With Dyskeratosis Congenita: A Report of Two Cases

Bikash Poudel, Abhishek Pandit, Mukesh Kumar Ranjan, Suraj Subedi, Josie Baral, Bigyan Maharjan, Pradeep Neupane, Ramesh Jha, Shraddha Uprety
article en

Abstract

Dyskeratosis congenita (DC) is a genetic disorder characterized by multisystem involvement. The most commonly affected systems are the mucocutaneous, bone marrow, and lungs. Though rare, chronic liver disease (CLD) has increasingly been reported to be associated with DC. The hepatic involvement can range from asymptomatic transaminasemia to end-stage liver disease. In this series, we present two cases of adult male patients with DC and decompensated CLD.

Clinical Case ReportsVol. 14(2)
Chitwan Medical College (NP)
Good health and well-being
Openalex Percentile: Top 53%
Telomeres, Telomerase, and Senescence
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Cirrhosis of Liver in Patients With Dyskeratosis Congenita: A Report of Two Cases — Bikash Poudel, Abhishek Pandit, et al. · Clinical Case Reports (2026) | TGRS Research Map | TGRS