Host response biomarkers of tuberculosis recurrence and treatment failure

These sputum-independent biomarkers effectively identify TB disease, non-conversion and recurrence TB after EOT, whereas their utility in detecting TB reversion during treatment remains limited.

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Publication Details

Journal
Communications Medicine
Published
2026-02-14
DOI
https://doi.org/10.1038/s43856-026-01424-w
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00

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article

Host response biomarkers of tuberculosis recurrence and treatment failure

Mkunde Chachage, Kairaba Kanyi, Gambia Sowe, Basil Sambou et al.
Communications Medicine
Tuberculosis Research and Epidemiology
article

Host response biomarkers of tuberculosis recurrence and treatment failure

Mkunde Chachage, Kairaba Kanyi, Gambia Sowe, Basil Sambou, Kavindhran Velen, Olga Baranov, Nelly Jinga, Azeezat Sallahdeen, Robert S. Wallis, V. Jani Ilesh, Lwitiho Sudi, Daniel Mapamba, Sanne Ian, Binta Sarr, Gavin Churchyard, Salieu Barry, Ulrich E. Schaible, Bernadette Bauer, Christof Geldmacher, Celina Nhamuave, Lyndel Singh, Farzana Sathar, Awa Touray, Abhishek Bakuli, Elmar Saathoff, Cândido Azize, Carla Madeira, Caleb Muefong, M Merker, Fadzai Munedzimwe, Shamanthi Jayasooriya, Fidelina Cumbe Zekoll, John D. Sutherland, Alhaji Jobe, I. Loum, Celso Khosa, Vânia Maphossa, Momodou W. Jallow, Khalide Azam, Rohey Jallow, Kathrin Held, Luming Lin, Emmanuel Sichone, Mohammed Naim Rassool, Mustapha Bah, Nádia Sitoe, Abi-Janet Riley, Julieth Lalashowi, Elimina Siyame, Cláudio Abujate, Nilesh Bhatt, Georgetta K. Daffeh, Simon D. Donkor, Viola Dreyer, Lindsay Zurba, Cristovão Matusse, Lamin Bah, Olena Ivanova, Abisai Kisinda, Simon Badjie, Jaclyn Bennet Denise Evans, Elvira Monteiro, Beate Kampmann, Monica Davies, Stefan Niemann, Knut Lönnroth, Issa Sabi, Anna-Maria Mekota, Olumuyiwa Owolabi, Kamban Hirasen, Salomão Manjate, Tina Minja, Alberto Machaze, Salome Charalambous, Mohamed I. M. Ahmed, Michael Hoelscher, Andrea Rachow, Ben Dowsing, Abdou Sillah, Sofia Viegas, Nyanda E. Ntinginya, Narciso Macie, Arlindo Machava
article en

Abstract

These sputum-independent biomarkers effectively identify TB disease, non-conversion and recurrence TB after EOT, whereas their utility in detecting TB reversion during treatment remains limited.

Communications Medicine
University of Dar es Salaam (TZ), University of the Witwatersrand (ZA), Karolinska Institutet (SE), Helmholtz Zentrum München (DE), LMU Klinikum (DE), Mbeya University of Science and Technology (TZ), Fraunhofer Institute for Translational Medicine and Pharmacology (DE), German Center for Infection Research (DE), MRC Unit the Gambia (GM), Aurum Institute (ZA), South African Sugarcane Research Institute (ZA), Research Center Borstel - Leibniz Lung Center (DE), Instituto Nacional de Saúde (MZ), Helen Joseph Hospital (ZA), Ministry of Health (MZ), Ludwig-Maximilians-Universität München (DE)
Deutsches Zentrum für Infektionsforschung, Bundesministerium für Bildung und Forschung
Good health and well-being
Openalex Percentile: Top 54%
Tuberculosis Research and Epidemiology
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