C-terminal Fragment Generated by HOIL-1 Cleavage Suppresses Inflammatory Responses of Myeloid Cells to Alleviate Colitis
Our results define the pathophysiological role of HOIL-1 cleavage in colitis, and unveil new functions of C-HOIL-1 in regulating myeloid inflammatory responses. These findings provide a potential therapeutic strategy for controlling gut inflammation in IBD.
Authors
- Henry Y. Lu (ORCID: https://orcid.org/0000-0002-1645-7748)
- Fung Shan-Yu
- Hefan Zhang
- Rui Li (ORCID: https://orcid.org/0009-0007-2684-1958)
- Qiuyun Chen
- Qian Wang
- Hailong Cao
- Yu Tian
- Hong Yang
- Rui Zhang
- Bangmao Wang
- Xingru Wang
- Christopher M. Overall
- Qianqian Li
Institutions
- University of British Columbia (CA)
- Tianjin Medical University General Hospital (CN)
- BC Children's Hospital (CA)
- Ministry of Education (KN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-11
- DOI
- https://doi.org/10.7150/thno.124294
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City
- Tianjin Science and Technology Committee
- Tianjin Medical University
- Tianjin Municipal Education Commission
- State Key Laboratory of Experimental Hematology
- Natural Science Foundation of Tianjin Municipal Science and Technology Commission