Age and the relation of common neuropathologies to dementia in Brazilian adults
In a community-based, clinical-pathologic study including 5300+ brains from diverse Brazilians, we show that AD and other common pathologies frequently begin in young adulthood. In older adults, mixed pathologies are most commonly associated with dementia, whereas in young adults a single pathology, most commonly chronic gross infarcts rather than ADNC is related to dementia.
Authors
- Victoria N. Poole (ORCID: https://orcid.org/0000-0003-0974-2564)
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- José M. Farfel (ORCID: https://orcid.org/0000-0003-2057-3669)
- Sukriti Nag
- Robert S Wilson
- Maria CM Sampaio
- David A Bennett
Institutions
- Rush University Medical Center (US)
- Chicago Department of Public Health (US)
- University of Chicago (US)
- Hospital do Servidor Público Estadual (BR)
- Instituto de Assistência Médica ao Servidor Público Estadual
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-14
- DOI
- https://doi.org/10.64898/2026.02.11.26346038
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Núcleo de Estudos, Pesquisa e Assessoria à Saúde
- National Institute on Aging