Identification of ALDH1A2-mediated cardioprotective benefits in myocardial ischaemia-reperfusion injury
In summary, our study indicates that Aldh1a2 is the central RA-producing enzyme mediating the protective effect against MIR injury and the following cardiac remodelling. Potentiating Aldh1a2 transcription and the downstream RA signalling is a potential means of treatment against MIR injury.
Authors
- Shanyu Gan
- Rong Wan (ORCID: https://orcid.org/0000-0003-1824-7135)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Siyi Zhou (ORCID: https://orcid.org/0000-0002-1022-3828)
- Jia Wang (ORCID: https://orcid.org/0000-0002-3846-2142)
- Yun Huang (ORCID: https://orcid.org/0000-0003-1549-1669)
- Lei Luo
- Cheng Xu (ORCID: https://orcid.org/0000-0003-1659-6198)
- Yufeng Hu
- Long Zhang
- Zhi-Gang She
- Xiao-Jing Zhang
- Jiayi Liu
- Yazhou Sun
- Wei Li
- Hailong Yang
Institutions
- Nanchang University (CN)
- Wuhan University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Gannan Medical University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/cvr/cvaf267
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00