Pachymic Acid Targets <scp>PI3K</scp> /Akt Signaling Pathway to Attenuate <scp>tPA</scp> ‐Induced Hemorrhagic Transformation After Ischemic Stroke
This study demonstrated that pachymic acid protects the BBB by targeting PI3K to activate the PI3K/Akt signaling pathway, thereby alleviating tPA-induced HT after ischemic stroke.
Authors
- Fangming Sun
- S. Zhang
- Ruoqi Li (ORCID: https://orcid.org/0000-0002-8343-6787)
- Tong Zhang (ORCID: https://orcid.org/0000-0002-5725-9510)
- Congmin Wei
- Fan Xiang (ORCID: https://orcid.org/0000-0003-1177-4602)
- YONGSHI Wu
- Yige Wu
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70782
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00