Elevated ferritin as a companion biomarker of myeloid-driven inflammation in RNP/Sm co-positive, treatment-resistant SLE endotype
Anti-RNP/Sm co-positivity defines a high-risk, flare-prone, myeloid-dominant SLE endotypeRNP⁺Sm⁺ patients, especially Black patients, show profound refractoriness to first-line and B-cell depletion therapiesExpanded intermediate monocytes with TLR4 upregulation and IFNA10-biased interferon signallingHyperferritinaemia correlates with disease activity exclusively in RNP⁺Sm⁺ patients.
Authors
- S Clare Chung
- Michael R. Ehrenstein (ORCID: https://orcid.org/0000-0003-1673-743X)
- Muhammad RA Shipa
- Daniel McClusky
- Laura Cooney
- Vincent Guichard
- Derek Gilroy
- Claire Beesley
Institutions
- University College Hospital (GB)
- University of California, San Francisco (US)
- Immune Tolerance Network (US)
- University College London (GB)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-14
- DOI
- https://doi.org/10.64898/2026.02.12.705402
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00