Left Inguino-Scrotal-Perineal Neurofibroma: A Report of a Rare Case and Review of Literature

Paratesticular masses arise from structures surrounding the testes, including the spermatic cord, epididymis, vestigial remnants, and tunica vaginalis. These masses are often benign, such as lipomas, leiomyomas, and adenomatoid tumors. Neurofibroma (NF) is a benign tumor of Schwann cell origin, characterized by strong S-100 protein expression. Neurofibromas typically occur in the face, shoulders, arms, periungual regions, and feet; the involvement of the inguino-scrotal region is extremely rare. We report a case of a 66-year-old man with a left inguino-scrotal mass of three years' duration that progressively enlarged and became painful. After a multidisciplinary review, surgical excision was performed. Histopathology and immunohistochemistry confirmed paratesticular neurofibroma. Neurofibroma should be considered in the differential diagnosis of paratesticular masses, and complete excision remains the treatment of choice.