Bruceine D ameliorates cholestatic liver injury by selectively modulating bile acid synthesis and activating FXR–SHP signaling
BD ameliorates cholestatic liver injury by selectively inhibiting classical BA synthesis, quantitatively remodeling the BA pool toward a less hepatotoxic profile, and suppressing inflammation and fibrosis through functional restoration of FXR-dependent feedback signaling. Its synthesis-centered mechanism and favorable short-term safety profile support BD as a promising therapeutic candidate for cholestatic liver diseases.
Authors
- Chuankui Fu (ORCID: https://orcid.org/0000-0001-7446-7410)
- Ruihua Huang
- Xiaoyun Zhu
- Qingui Sun
- Wei Jiang
Institutions
- Central South University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.phymed.2026.157972
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00