Investigation of the role of ILC2 in middle ear mucosa using a novel model of eosinophilic otitis media
This is the first report on Papain-induced allergic disease models in the middle ear. In the stimulated group, hyperproduction of mucin containing eosinophils in the tympanic cavity and increased ILC2s in the mucosa were observed. The novel model presented in this study may contribute to the elucidation of the pathogenesis of EOM as a type 2 inflammation.
Authors
- Junko Takahata
- Atsushi Matsubara (ORCID: https://orcid.org/0000-0003-0715-9543)
- Daisuke Matsushita (ORCID: https://orcid.org/0000-0003-2021-4092)
- Kei Matsushita
- Satoshi Suzuki
- Naomi Kudo
- Tomoaki Fujita
Institutions
- Hirosaki University (JP)
- Hirosaki University Hospital (JP)
Publication Details
- Journal
- Auris Nasus Larynx
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.anl.2026.02.005
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00