Survival from severe generalized tetanus complicated by seizures and multidrug-resistant septic shock: A case report

Tetanus, a vaccine-preventable disease caused by the neurotoxin of Clostridium tetani , remains a significant cause of morbidity and mortality, particularly in low-income countries with inadequate immunization coverage. Severe generalized tetanus, the most common clinical presentation, is characterized by excruciating muscle spasms, rigidity, and autonomic nervous system dysfunction, often necessitating intensive care unit (ICU) admission. The prognosis is further worsened by life-threatening complications such as respiratory failure and sepsis. We present the case of a 49-year-old male with severe generalized tetanus following a contaminated wound, whose hospital course was complicated by multidrug-resistant septic shock. Despite a prolonged and challenging ICU stay, the patient made a remarkable and complete neurological recovery. This case highlights the critical importance of early diagnosis, aggressive multidisciplinary ICU management, and comprehensive rehabilitation in achieving favorable outcomes in the face of overwhelming complications.