Systemic immune-metabolic interactions in patients with amyotrophic lateral sclerosis: correlations of plasma cytokines with metabolic status
Findings confirm modest elevations in plasma levels of IL-6 and MCP-1 in ALS but provide no evidence that circulating cytokines correlate with hypermetabolism. Further studies integrating longitudinal and tissue-specific analyses are needed to clarify immune-metabolic mechanisms contributing to disease heterogeneity in ALS.
Authors
- Cory J. Holdom (ORCID: https://orcid.org/0000-0001-5972-6437)
- Stephanie L. Howe (ORCID: https://orcid.org/0000-0001-8518-7721)
- Shyuan Ngo
- Robert D. Henderson
- Frederik J. Steyn
- Pamela A. McCombe
Institutions
- The University of Queensland (AU)
- Royal Brisbane and Women's Hospital (AU)
- Institute of Bioengineering and Nanotechnology (SG)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1080/21678421.2026.2627902
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00