CD44/POU2F2/BCL9L axis mediates MIF-driven SPP1 <sup>+</sup> TAM activation in colorectal cancer metastasis
Our findings suggest that the MIF/CD44/POU2F2/BCL9L signaling axis is involved in the proangiogenic capacity of activated SPP1<sup>+</sup>TAMs, thereby enhances CRC metastasis. Targeting this novel signaling axis can effectively suppress the SPP1<sup>+</sup>TAM activation, which represents a promising and pivotal strategy for managing CRC metastasis.
Authors
- Haibo Zhang (ORCID: https://orcid.org/0000-0002-1714-3038)
- Tao Su
- Bingquan Zhao
- Xueying Fan
- Fan Zhang
- Hiu-Yee Kwan
- Zhiqiang Shi
- Peilan Guo
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hong Kong Baptist University (HK)
- Ji Hua Laboratory (CN)
Publication Details
- Journal
- International Journal of Biological Sciences
- Published
- 2026-02-04
- DOI
- https://doi.org/10.7150/ijbs.116575
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China