Global Emergence and Spread of the XFG SARS-CoV-2 Variant and Its Clinical Profile Among XFG Patients in Maharashtra, India

The XFG variant emerged as the dominant SARS-CoV-2 lineage globally during late 2024-2025 and circulated widely across India, with a brief mid-2025 surge. Despite reduced clinical severity, XFG's rapid spread and diversification highlight ongoing viral adaptability and the need for strengthened, complementary surveillance to detect emerging variants early.

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Publication Details

Journal
Cureus
Published
2026-02-14
DOI
https://doi.org/10.7759/cureus.103574
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Global Emergence and Spread of the XFG SARS-CoV-2 Variant and Its Clinical Profile Among XFG Patients in Maharashtra, India

Jyoti J. Gurav, P Pawar, Suvarna Joshi, Rajesh Karyakarte et al.
Cureus
SARS-CoV-2 and COVID-19 Research
article

Global Emergence and Spread of the XFG SARS-CoV-2 Variant and Its Clinical Profile Among XFG Patients in Maharashtra, India

Jyoti J. Gurav, P Pawar, Suvarna Joshi, Rajesh Karyakarte, Rashmita Das, Y Sushma, Gilbert Chamy, Kalyani Jagarwal, Damini More, Asawari Koshti, Poonam Madne, Anna Tete, Vandana Patil, Vasundhara Singh, Viswanathan D V
article en

Abstract

The XFG variant emerged as the dominant SARS-CoV-2 lineage globally during late 2024-2025 and circulated widely across India, with a brief mid-2025 surge. Despite reduced clinical severity, XFG's rapid spread and diversification highlight ongoing viral adaptability and the need for strengthened, complementary surveillance to detect emerging variants early.

CureusVol. 18(2)
Government of Maharashtra (IN), B. J. Medical College & Sassoon Hospital (IN)
Partnerships for the goals
Openalex Percentile: Top 55%
SARS-CoV-2 and COVID-19 Research
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