Identifying Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma: An Uncommon Case of Ocular Adnexal Lymphoma

Chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) are typically classified and treated as different manifestations of the same disease. Compared to the Western hemisphere, this type of lymphoma is rare in Asian countries. They usually manifest as anaemia, organomegaly, or lymphadenopathy. Ocular adnexal lymphoma (OAL) is a rare presentation of lymphoma that can affect any part of the orbital region. We present a gentleman who sought treatment at our centre for this rare malignancy, with an atypical presentation of painless swelling over the upper eyelid. The initial diagnosis of hematoma secondary to trauma was swiftly discarded following surgery, revealing a lobulated mass. Subsequently, histopathological examination points towards a diagnosis of CLL/SLL. We illustrate the importance of multidisciplinary management with several departments, striving to achieve the best possible outcome.

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Journal
Cureus
Published
2026-02-14
DOI
https://doi.org/10.7759/cureus.103586
Primary Topic
Chronic Lymphocytic Leukemia Research
Type
article
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article

Identifying Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma: An Uncommon Case of Ocular Adnexal Lymphoma

Xiong Khee Cheong, Nordashima Abd Shukor, Sivakumar Palaniappan, Nor Rafeah Tumian et al.
Cureus
Chronic Lymphocytic Leukemia Research
article

Identifying Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma: An Uncommon Case of Ocular Adnexal Lymphoma

Xiong Khee Cheong, Nordashima Abd Shukor, Sivakumar Palaniappan, Nor Rafeah Tumian, Subo Chang, Alia Suzana Asri, Juen Kiem Tan, Chia Yin Chong, S Fadilah Abdul Wahid, Othmaliza O
article en

Abstract

Chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) are typically classified and treated as different manifestations of the same disease. Compared to the Western hemisphere, this type of lymphoma is rare in Asian countries. They usually manifest as anaemia, organomegaly, or lymphadenopathy. Ocular adnexal lymphoma (OAL) is a rare presentation of lymphoma that can affect any part of the orbital region. We present a gentleman who sought treatment at our centre for this rare malignancy, with an atypical presentation of painless swelling over the upper eyelid. The initial diagnosis of hematoma secondary to trauma was swiftly discarded following surgery, revealing a lobulated mass. Subsequently, histopathological examination points towards a diagnosis of CLL/SLL. We illustrate the importance of multidisciplinary management with several departments, striving to achieve the best possible outcome.

CureusVol. 18(2)
Hospital Kuala Lumpur (MY), University Kebangsaan Malaysia Medical Centre (MY), National University of Malaysia (MY)
Good health and well-being
Openalex Percentile: Top 56%
Chronic Lymphocytic Leukemia Research
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Identifying Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma: An Uncommon Case of Ocular Adnexal Lymphoma — Xiong Khee Cheong, Nordashima Abd Shukor, et al. · Cureus (2026) | TGRS Research Map | TGRS