Angiotensin <scp>II</scp> Receptor‐Associated Protein ( <scp>AGTRAP</scp> ) Enhances Glioma Cell Survival Through the <scp>IL</scp> ‐6/ <scp>JAK2</scp> / <scp>STAT3</scp> Pathway and Correlates With an Immunosuppressive Microenvironment
AGTRAP supports glioma cell survival by engaging an IL-6-linked JAK2/STAT3 program and is associated with a macrophage-rich, inflammatory tumor microenvironment. These findings suggest that AGTRAP may serve as a candidate intervention target for gliomas.
Authors
- Sheng Qiu (ORCID: https://orcid.org/0000-0001-8391-9298)
- Xiaoxing Xiong (ORCID: https://orcid.org/0000-0001-6983-8547)
- Yonggang Zhang (ORCID: https://orcid.org/0000-0002-6572-8487)
- Xiaohu Nie (ORCID: https://orcid.org/0000-0002-7346-5672)
- Qianxue Chen (ORCID: https://orcid.org/0000-0002-9413-1030)
- Yuntao Li
- Zhongzhou Su
- Siyu Chen
Institutions
- Huzhou Normal University (CN)
- Huzhou Central Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70796
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00