Pharmacotherapy for Alcohol Craving Reduction: Efficacy of Short-Term Treatments in Alcohol Use Disorder

This review suggests that naltrexone and varenicline appear to be the most consistently supported short-term pharmacotherapies for alcohol craving within the available evidence, with promising but less consistent findings for memantine, acamprosate, and topiramate. These results highlight potential candidates for immediate craving management in AUD, while underscoring the need for larger and longer-term trials to confirm their efficacy and safety.

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Publication Details

Journal
Medicines
Published
2026-02-14
DOI
https://doi.org/10.3390/medicines13010007
Primary Topic
Substance Abuse Treatment and Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Pharmacotherapy for Alcohol Craving Reduction: Efficacy of Short-Term Treatments in Alcohol Use Disorder

Matheus Cheibub David Marin, Giuliana Perrotte, Maria Olívia Pozzolo Pedro, João Mauricio Castaldelli-Maia
Medicines
Substance Abuse Treatment and Outcomes
article

Pharmacotherapy for Alcohol Craving Reduction: Efficacy of Short-Term Treatments in Alcohol Use Disorder

Matheus Cheibub David Marin, Giuliana Perrotte, Maria Olívia Pozzolo Pedro, João Mauricio Castaldelli-Maia
article en

Abstract

This review suggests that naltrexone and varenicline appear to be the most consistently supported short-term pharmacotherapies for alcohol craving within the available evidence, with promising but less consistent findings for memantine, acamprosate, and topiramate. These results highlight potential candidates for immediate craving management in AUD, while underscoring the need for larger and longer-term trials to confirm their efficacy and safety.

MedicinesVol. 13(1)
Universidade de São Paulo (BR)
Reduced inequalities
Openalex Percentile: Top 55%
Substance Abuse Treatment and Outcomes
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