Hypogammaglobulinemia at Leukapheresis Predicts Delayed Humoral Immune Reconstitution and Increased Risk of Infections After CD19 CAR-T for B-Cell Lymphoma

Hypogammaglobulinemia at leukapheresis is a simple yet informative biomarker that predicts delayed humoral immune recovery, increased infectious events, and treatment-related mortality after CD19 CAR-T therapy in B-cell lymphoma. Moreover, it represents an independent risk factor for post-CD19 CAR-T infections, separate from neutrophil and lymphocyte recovery.

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Publication Details

Journal
Transplantation and Cellular Therapy
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jtct.2026.02.046
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

Hypogammaglobulinemia at Leukapheresis Predicts Delayed Humoral Immune Reconstitution and Increased Risk of Infections After CD19 CAR-T for B-Cell Lymphoma

Aya Nishida, Kosei Kageyama, Shinsuke Takagi, Yuki Taya et al.
Transplantation and Cellular Therapy
CAR-T cell therapy research
article

Hypogammaglobulinemia at Leukapheresis Predicts Delayed Humoral Immune Reconstitution and Increased Risk of Infections After CD19 CAR-T for B-Cell Lymphoma

Aya Nishida, Kosei Kageyama, Shinsuke Takagi, Yuki Taya, Atsushi Wake, Kyosuke Yamaguchi, Yuki Asano-Mori, Hisashi Yamamoto, Tatsuro Hirao, Daisuke Kaji, Naoyuki Uchida, Mika Kuno, Go Yamamoto, Otoya Watanabe
article en

Abstract

Hypogammaglobulinemia at leukapheresis is a simple yet informative biomarker that predicts delayed humoral immune recovery, increased infectious events, and treatment-related mortality after CD19 CAR-T therapy in B-cell lymphoma. Moreover, it represents an independent risk factor for post-CD19 CAR-T infections, separate from neutrophil and lymphocyte recovery.

Transplantation and Cellular Therapy
Toranomon Hospital (JP)
Good health and well-being
Openalex Percentile: Top 55%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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Hypogammaglobulinemia at Leukapheresis Predicts Delayed Humoral Immune Reconstitution and Increased Risk of Infections After CD19 CAR-T for B-Cell Lymphoma — Aya Nishida, Kosei Kageyama, et al. · Transplantation and Cellular Therapy (2026) | TGRS Research Map | TGRS