Head and Neck Squamous Cell Carcinoma Patient-Derived Cancer-Associated Fibroblasts Undergo Senescence While Retaining Protumorigenic Properties After Ex Vivo Irradiation
This work highlights the importance of CAFs in RT and offers rationale for exploring combinations of RT and CAF-targeting approaches in HNSCC.
Authors
- Gosse J. Adema (ORCID: https://orcid.org/0000-0002-6750-1665)
- Anne P.M. Beerkens
- Jimmie Honings (ORCID: https://orcid.org/0000-0001-5077-3472)
- Willem L. J. Weijs
- Marleen Ansems (ORCID: https://orcid.org/0000-0003-0196-5755)
- Kris Raaijmakers (ORCID: https://orcid.org/0009-0001-7795-4887)
- Johannes H.A.M. Kaanders (ORCID: https://orcid.org/0000-0001-5374-9558)
- Johan Bussink
- Maud Beekmans
- Rens H.W. Peters
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.ijrobp.2026.02.209
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universitair Medisch Centrum