Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles accelerate diabetic wound healing by reprogramming fibroblast subpopulations and delivering pro-regenerative cargos
Our study revealed that hUC-MSC-sEVs accelerated diabetic wound healing through a dual mechanism: by reprogramming fibroblast subpopulations and by delivering pro-regenerative cargos (via functionally distinct sEV subpopulations enriched with immunomodulatory and reparative factors). These findings elucidate the molecular and cellular basis for hUC-MSC-sEV efficacy and provide a novel theoretical foundation for EV-based therapies in diabetic wound repair.
Authors
- Hangqi Gao
- Penghong Chen (ORCID: https://orcid.org/0000-0003-2528-1008)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- C. L. Philip Chen (ORCID: https://orcid.org/0000-0001-5451-7230)
- Guohua Wu (ORCID: https://orcid.org/0000-0001-5385-4235)
- Jiansheng Zheng
- Yu Fu
- Siqin Yang
- Zhaohong Chen
Institutions
- Fujian Medical University (CN)
- 175th Hospital of People's Liberation Army (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Union Hospital (US)
- Union Hospital (CN)
Publication Details
- Journal
- Burns
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.burns.2026.107910
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00