FORMULATION AND EVALUATION OF DOXOPHYLINE SUSTAINED RELEASE TABLETS USING DIFFERENT POLYMERS

Doxophylline, a xanthine derivative, is commonly used for the treatment and prevention of asthma due to its bronchodilator properties. The present study focuses on the formulation and evaluation of sustained-release tablets of doxophylline using different polymers. Two formulations were prepared: F1 by direct compression (slugging method) and F2 by wet granulation method. Both formulations contained doxophylline (650 mg), microcrystalline cellulose (MCC PH102), and hydroxypropyl methylcellulose (HPMC K100M) in varying proportions, along with talc and magnesium stearate. Preformulation studies indicated favorable physicochemical properties such as good solubility, bulk density, and compressibility. Granules were evaluated for angle of repose, bulk density, Carr’s index, and Hausner’s ratio, revealing excellent flow properties especially after lubrication. Tablets were assessed for weight variation, hardness, friability, disintegration, and drug content uniformity. The results showed that both formulations complied with standard pharmacopoeial limits and exhibited good mechanical strength and controlled release characteristics. The study demonstrates that HPMC K100M-based sustained-release tablets can effectively deliver doxophylline, enhancing therapeutic efficacy and patient compliance.