SMARCA4 deficiency in glioblastoma: Mitochondrial transfer from MSCs and the clinical dilemma in targeting the tumor microenvironment
Our findings highlight SMARCA4's critical role in regulating MSC function within the GBM microenvironment. Targeting SMARCA4-mediated mitochondrial transfer in MSCs may represent a novel therapeutic strategy for GBM.
Authors
- Yuchen Shi (ORCID: https://orcid.org/0000-0002-1885-8043)
- Minfeng Tong
- Lude Wang
- Fan Yang
- Lin Chen
Institutions
- Jinhua Academy of Agricultural Sciences (CN)
- Guang Fu Hospital (CN)
- Jinhua University of Vocational Technology (CN)
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.neo.2026.101288
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00