The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

hCG exhibits a dual nature: essential for reproduction and immune adaptation, yet potentially neurotoxic under dysregulated conditions. This review synthesizes mechanistic hypotheses, highlights knowledge gaps, and underscores the need for rigorous longitudinal and experimental studies to clarify hCG's impact on the nervous system.

Authors

Institutions

Publication Details

Journal
Archives of Gynecology and Obstetrics
Published
2026-02-14
DOI
https://doi.org/10.1007/s00404-025-08251-9
Primary Topic
Hypothalamic control of reproductive hormones
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

Tayebeh Esfidani, Atoosa Etezadi, Nadia Talati Reveshti, Seyedehmaryam Hosseini et al.
Archives of Gynecology and Obstetrics
Hypothalamic control of reproductive hormones
article

The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

Tayebeh Esfidani, Atoosa Etezadi, Nadia Talati Reveshti, Seyedehmaryam Hosseini, Hanie Babaei, Pedram Ghanavati
article en

Abstract

hCG exhibits a dual nature: essential for reproduction and immune adaptation, yet potentially neurotoxic under dysregulated conditions. This review synthesizes mechanistic hypotheses, highlights knowledge gaps, and underscores the need for rigorous longitudinal and experimental studies to clarify hCG's impact on the nervous system.

Archives of Gynecology and ObstetricsVol. 313(1)
Iran University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR), Guilan University of Medical Sciences (IR), Firoozgar General Hospital (IR), Hormozgan University of Medical Sciences (IR), Shahid Beheshti University of Medical Sciences (IR)
Zero hunger
Openalex Percentile: Top 57%
Hypothalamic control of reproductive hormones
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.