IFNL4 genotype is associated with hepatitis A virus infection: Findings from a focused phenotype study in the UK Biobank Cohort
We report a novel protective association between the IFNL4-ΔG allele, which generates IFN-λ4 protein, and HAV infection. Future studies might examine the mechanism for this association and the therapeutic potential of IFN-λ4 for treating infection with HAV.
Authors
- Aubrey K. Hubbard (ORCID: https://orcid.org/0000-0003-4052-1110)
- Ludmila Prokunina‐Olsson (ORCID: https://orcid.org/0000-0002-9622-2091)
- Neha Agarwala (ORCID: https://orcid.org/0000-0002-9975-9492)
- EA Engels
- William Wheeler
- Ruth M. Pfeiffer
- Minkyo Song
- Mitchell J. Machiela
- Marc G. Ghany
- Thomas R. O’Brien
Institutions
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Information Management Services (US)
- National Institute on Aging (US)
- National Cancer Institute (US)
- Division of Cancer Epidemiology and Genetics
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.ijid.2026.108483
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases