Corneal confocal microscopy and cardiac autonomic neuropathy in individuals with type 1 diabetes mellitus

In individuals with T1DM, the presence of CAN and higher BMI were independently associated with reduced CNFL. These findings indicate an association between corneal small-fiber pathology and autonomic dysfunction in T1DM, supporting the role of CCM as a non-invasive measure of neuropathy burden, while longitudinal studies are required to determine its diagnostic or prognostic utility.

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Publication Details

Journal
Journal of Diabetes and its Complications
Published
2026-02-14
DOI
https://doi.org/10.1016/j.jdiacomp.2026.109290
Primary Topic
Corneal surgery and disorders
Type
article
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article

Corneal confocal microscopy and cardiac autonomic neuropathy in individuals with type 1 diabetes mellitus

Stamatia Simati, Anastasios Tentolouris, I. Eleftheriadou, PANAGIOTIS G. THEODOSSIADIS et al.
Journal of Diabetes and its Complications
Corneal surgery and disorders
article

Corneal confocal microscopy and cardiac autonomic neuropathy in individuals with type 1 diabetes mellitus

Stamatia Simati, Anastasios Tentolouris, I. Eleftheriadou, PANAGIOTIS G. THEODOSSIADIS, Adamantia Voudouri, Maria Ziori, Evaggelia K. Aissopou, Ioanna A. Anastasiou, Nikolaos Tentolouris
article en

Abstract

In individuals with T1DM, the presence of CAN and higher BMI were independently associated with reduced CNFL. These findings indicate an association between corneal small-fiber pathology and autonomic dysfunction in T1DM, supporting the role of CCM as a non-invasive measure of neuropathy burden, while longitudinal studies are required to determine its diagnostic or prognostic utility.

Journal of Diabetes and its ComplicationsVol. 40(4)
National and Kapodistrian University of Athens (GR), Laiko General Hospital of Athens (GR), Athens Eye Hospital (GR), University General Hospital Attikon (GR), Eginition Hospital (GR)
Good health and well-being
Openalex Percentile: Top 55%
Corneal surgery and disorders
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