Neuropsychological Profile of Normal Pressure Hydrocephalus: A Systematic Review of Cognitive Trajectories and Evidence-Based Assessment Tools for Surgical Management

Cognitive recovery after shunt in NPH follows a predominantly fronto-subcortical pattern, with the greatest improvements occurring within the first postoperative year. MMSE, TMT-A, TMT-B, and Digit Span represent the most reliable and informative neuropsychological tools for preoperative and postoperative evaluation and should constitute the core of a standardized NPH-specific cognitive battery. Establishing uniform testing protocols and improving methodological consistency across studies will enhance diagnostic accuracy, surgical decision-making, and long-term monitoring of this treatable condition.

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Publication Details

Journal
World Neurosurgery
Published
2026-02-14
DOI
https://doi.org/10.1016/j.wneu.2026.124868
Primary Topic
Cerebrospinal fluid and hydrocephalus
Type
article
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article

Neuropsychological Profile of Normal Pressure Hydrocephalus: A Systematic Review of Cognitive Trajectories and Evidence-Based Assessment Tools for Surgical Management

Gianluca Scalia, Grazia Razza, Rosalba Pitoia, Francesca Graziano et al.
World Neurosurgery
Cerebrospinal fluid and hydrocephalus
article

Neuropsychological Profile of Normal Pressure Hydrocephalus: A Systematic Review of Cognitive Trajectories and Evidence-Based Assessment Tools for Surgical Management

Gianluca Scalia, Grazia Razza, Rosalba Pitoia, Francesca Graziano, Giovanni Nicoletti, Roberta Finocchiaro, Lisa Passarello
article en

Abstract

Cognitive recovery after shunt in NPH follows a predominantly fronto-subcortical pattern, with the greatest improvements occurring within the first postoperative year. MMSE, TMT-A, TMT-B, and Digit Span represent the most reliable and informative neuropsychological tools for preoperative and postoperative evaluation and should constitute the core of a standardized NPH-specific cognitive battery. Establishing uniform testing protocols and improving methodological consistency across studies will enhance diagnostic accuracy, surgical decision-making, and long-term monitoring of this treatable condition.

World NeurosurgeryVol. 208
University of Catania (IT), Ospedale Garibaldi (IT)
Peace, Justice and strong institutions
Openalex Percentile: Top 57%
Cerebrospinal fluid and hydrocephalus
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