Associations of Arterial Blood Pressure With Radiographic Knee Osteoarthritis and Pain Sensitivity in Middle‐Aged and Older Adults

Associations between arterial blood pressure and pain in older adults with knee pain were found to be sex- and hypertension-dependent, primarily evident in normotensive individuals. Elevated blood pressure was associated with reduced mechanical pain sensitivity but greater radiographic OA in normotensive males; normotensive females showed enhanced pain facilitation without increased OA severity. These findings support arterial pressure as a shared vascular factor in pain-pathology mismatch and highlight the importance of incorporating cardiovascular markers into chronic pain phenotyping and interpretation.