Vagus nerve stimulation for drug‐resistant epilepsy and predictors for seizure freedom: A nationwide multicenter cohort study in Mexico
Vagus nerve stimulation was associated with substantial seizure frequency reduction, lower morbidity, and less healthcare utilization, with a favorable safety profile. Baseline seizure burden emerged as the key predictor of seizure freedom and may guide patient selection, supporting earlier vagus nerve stimulation consideration in drug-resistant epilepsy.
Authors
- Sonia Iliana Mejía‐Pérez (ORCID: https://orcid.org/0000-0002-5929-6761)
- Irene Gómez‐Oropeza
- María F Castelo-Pablos
- José A. Infante‐Cantú
- Manuel C. Porras‐Betancourt
- Samuel Pérez‐Cardenas
- Horacio Sentíes‐Madrid
- Matilde Ruiz‐Garcia
- Juan C. Reséndiz‐Aparicio
- Noel Plascencia‐Álvarez
- Diego A. Barrera‐Tovar
- Mario A. Alonso‐Vanegas
- Denisse Romero‐García
- Elma Paredes‐Aragón
- María I. Alanís‐Guevara
- Avril Molina‐García
- Roberto A. Lugo‐Guillén
- Immer Armendáriz‐Betancourt
- Araceli Reyes‐Cuayahuitl
- Alma M. Huerta‐Hurtado
- Giovanny Soca‐Chafre
Institutions
- Autonomous University of Chihuahua (MX)
- Mexican Social Security Institute (MX)
- Oasis of Hope Hospital (MX)
- Instituto de Neurociencias (ES)
- Hospital Infantil de México Federico Gómez (MX)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Hospital Zambrano Hellion (MX)
- Universidad Regional del Norte (MX)
- Centro Medico Nacional Siglo XXI (MX)
- Hospital de Especialidades (MX)
- Instituto Nacional de Pediatria (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Epilepsy Foundation (AU)
- Fundar (MX)
- Centro Universitario de Chihuahua (MX)
- Institute for Social Security and Services for State Workers (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1002/epd2.70202
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00