Second to Fourth Digit Ratio ( <scp>2D</scp> : <scp>4D</scp> ) in Female Patients With Systemic Sclerosis: Evidence for Prenatal Androgen Exposure

Female SSc patients exhibit significantly lower 2D:4D ratios than healthy controls, suggesting higher prenatal testosterone exposure. These findings support the hypothesis that the prenatal hormonal environment may contribute to autoimmune disease susceptibility.