Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats
Repeated systemic IL-4 administration after SCI promotes functional recovery, shifts macrophage polarization toward a regenerative phenotype, reduces astrogliosis and oligodendrocyte loss, and suppresses systemic inflammation. Multi-omics integration together with patient data suggests IL-4 targets convergent pathways of neuroprotection and immune modulation, supporting its further development as a therapeutic candidate for SCI.
Authors
- GuoLi Zheng
- Xiaowei Zha
- Christian Patrick Schaaf (ORCID: https://orcid.org/0000-0002-2148-7490)
- Stefan Heene
- Johannes Walter (ORCID: https://orcid.org/0000-0001-8579-5612)
- Tim Schubert (ORCID: https://orcid.org/0009-0003-1696-4402)
- Bahram Biglari (ORCID: https://orcid.org/0000-0003-4500-6564)
- Klaus Zweckberger
- Karl Kiening
- Alexander Younsi
- Obada Taleb Alhalabi
- Thomas Skutella
- Xing-Jin Wang
- Sandro Manuel Krieg
- Marcin Luzarowski
- Raban Heller
- Laura Ruebenacker
- Andreas Wilhelm Unterberg
- Lea Hansen-Palmus
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- Brunswick (United States) (US)
- Humboldt-Universität zu Berlin (DE)
- Armed Forces Hospital (SA)
- Institute of Human Genetics (PL)
- Klinikum Ludwigshafen (DE)
- European Molecular Biology Laboratory (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Technische Universität Berlin (DE)
- Heidelberg University (US)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-11
- DOI
- https://doi.org/10.7150/thno.123815
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft