Identification of the Inflammatory Cytokine Tumor Necrosis Factor Superfamily 4 as an Oncogenic Driver and Potential Druggable Target in Hepatocellular Carcinoma
TNFSF4 was a candidate driver and a prognostic biomarker, promoting HCC progression by activating the PI3K/Akt signaling pathway. Furthermore, fluspirilene may have applications as a repositioned drug for HCC with high TNFSF4 expression.
Authors
- Yusuke Nakano (ORCID: https://orcid.org/0000-0002-7718-7446)
- Kiyotaka Hosoda (ORCID: https://orcid.org/0000-0001-6928-3676)
- Takashi Ofuchi (ORCID: https://orcid.org/0000-0001-6219-5278)
- Takaaki MASUDA
- Katsushi Dairaku
- Taro Tobo
- Kazuki Omachi
- Masahiro Hashimoto (ORCID: https://orcid.org/0000-0002-9264-6057)
- Chihiro Matsumoto (ORCID: https://orcid.org/0009-0000-8361-6414)
- Tomohiko Ikehara
- Akira Shimizu (ORCID: https://orcid.org/0000-0002-9475-9661)
- Hideyuki Saito (ORCID: https://orcid.org/0000-0002-8927-6470)
- Yusuke Yonemura
- Koto Kawata
- Yuki Ando
- Hajime Otsu
- Y. Tsuda
- Kosuke Hirose
- Koshi Mimori
- Kensuke Koike
- Tadashi Abe
- Yuji Soejima
Institutions
- Shinshu University (JP)
- Kochi Medical School Hospital (JP)
- Kyushu University Beppu Hospital (JP)
- Kōchi University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1111/hepr.70135
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Takamatsu Cancer Research Fund
- Japan Society for the Promotion of Science