Characterizing TDP‐43 involvement in vascular dementia
Tar DNA-binding protein 43 (TDP-43) is dysregulated early in vascular dementia models. Hypoperfusion triggers TDP-43 mislocalization and phosphorylation. TDP-43 pathology is absent in late-stage human vascular dementia. TDP-43 is a transient, novel target for vascular cognitive impairment.
Authors
- Yuek Ling Chai (ORCID: https://orcid.org/0000-0001-6646-1553)
- Thiruma V. Arumugam (ORCID: https://orcid.org/0000-0002-3377-0939)
- Vernise J. T. Lim
- Raj N Kalaria
- Dong‐Gyu Jo
- Marconi Fung
- Christopher P. Chen
- Mitchell K. P. Lai
- Nishat Tabassum
- Yi‐Lin Cheng
Institutions
- National University of Singapore (SG)
- La Trobe University (AU)
- National University Health System (SG)
- Sungkyunkwan University (KR)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71196
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- La Trobe University
- Medical Research Council
- National Health and Medical Research Council
- National Medical Research Council