Plasma ATN biomarkers across the alzheimer’s disease continuum in a Chilean community- and clinic-based cohort
These findings support the biological consistency of plasma biomarkers in AD-related neurodegeneration and provide novel evidence from a Latin American population. Further studies are needed to improve early-stage detection and to better understand how genetic, environmental, and health factors shape biomarker expressions in underrepresented regions.
Authors
- Matías Pizarro (ORCID: https://orcid.org/0009-0005-7397-1515)
- Patricio A. Riquelme (ORCID: https://orcid.org/0009-0005-4793-565X)
- Paulina Orellana (ORCID: https://orcid.org/0000-0001-8752-7750)
- Felipe A. Court (ORCID: https://orcid.org/0000-0002-9394-7601)
- Rolando De la cruz
- Patricia Andreo Lillo
- Ariel Caviedes (ORCID: https://orcid.org/0000-0003-4373-5587)
- Roque Villagra (ORCID: https://orcid.org/0000-0002-4388-4833)
- Francisca Damm
- Natalia Pozo
- Nickole Marín-Díaz
- Hernan Hernandez
- Carolina Gonzalez-Silva
- Pamela C L. Ferreira
- Daniela Thumala-Dockendorff
- Claudia Duran-Aniotz
- Felipe Cabral-Miranda
- Agustín Ibañez
- Bruna Bellaver
- Thomas K Karikari
- Mauricio Cerda
- Fernando Henríquez
Institutions
- Universidad Mayor (CL)
- Universidade Federal do Rio de Janeiro (BR)
- Universidad del Desarrollo (CL)
- Buck Institute for Research on Aging (US)
- University of Wisconsin–Madison (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Pontificia Universidad Católica de Chile (CL)
- University of Pittsburgh (US)
- Trinity College Dublin (IE)
- Adolfo Ibáñez University (CL)
- Sahlgrenska University Hospital (SE)
- Istanbul Medipol University (TR)
- University of San Andrés (AR)
- Hospital del Salvador (CL)
- Pasqual Maragall Foundation (ES)
- Fundación Ciencia and Vida (CL)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Instituto de Neurociencia Biomédica (CL)
- National Hospital for Neurology and Neurosurgery (GB)
- Global Brain Health Institute (US)
- Hospital San Borja Arriarán (CL)
- Millennium Institute for Integrative Biology (CL)
- Data Observatory Foundation
- University College London (GB)
- University of Chile (CL)
- University of Valparaíso (CL)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s13195-026-01974-0
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00