Nonthermal radiofrequency radiation promotes hematopoietic stem and progenitor cells function by regulating Ca2+ efflux
Our results provided the first evidence that non-thermal RFR can improve HSPCs function. The central mechanism involved RFR-induced plasma membrane fluidity, activation of PMCA, thus accelerating Ca<sup>2+</sup> efflux and maintaining HSPCs in a metabolically quiescent state. This work provided transformative insights into electromagnetic field biology and potential transplantation strategies for radiation-induced hematopoietic injury.
Authors
- J H Li
- Ke Zhao (ORCID: https://orcid.org/0000-0002-8262-4989)
- Xiongwei Zhao
- Yang Xue
- Changyan Li (ORCID: https://orcid.org/0009-0009-5908-4708)
- S. Li
- Xiaoming Yang
- Huiying Sun
- Shensi Xiang
- Anyu Xu
- Huiying Gao
- Yunqiang Wu
- Zhichun Lv
Institutions
- Anhui Medical University (CN)
- Beijing Proteome Research Center (CN)
- Hebei University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s13287-026-04937-2
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00