Effect of type I collagen on TLR-3 induced MMP-13 expression in human periodontal ligament fibroblasts
This study provides evidence for an interaction between extracellular matrix signals and innate immune activation. Type I collagen promoted hPDL fibroblast migration, whereas poly I:C-a TLR3 agonist-upregulated MMP-13 expression, with the greatest effect observed in combination with collagen.
Authors
- Nirada Dhanesuan (ORCID: https://orcid.org/0009-0004-9438-139X)
- Siriluck Tiranathanagul
- Ratthawut Namwad
- Pitchaya Chaiyaraksa
Institutions
- Srinakharinwirot University (TH)
Publication Details
- Journal
- Journal of Oral Biology and Craniofacial Research
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.jobcr.2026.101420
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00