CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation

This study reveals that CXCL8 drives OSCC metastasis via CXCR1/2-mediated JAK1/STAT3 activation leading to MMP1 transcriptional upregulation. Our findings establish CXCL8 as both a prognostic biomarker and a promising therapeutic target, and suggest that targeting this pathway offers significant therapeutic potential for preventing OSCC metastatic progression.

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Publication Details

Journal
International Journal of Biological Sciences
Published
2026-02-01
DOI
https://doi.org/10.7150/ijbs.115990
Primary Topic
Chemokine receptors and signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation

Ju-fang Liu, Ying-Sui Sun, Tsung-Ming Chang, Chih-Hsin Tang et al.
International Journal of Biological Sciences
Chemokine receptors and signaling
article

CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation

Ju-fang Liu, Ying-Sui Sun, Tsung-Ming Chang, Chih-Hsin Tang, Kuan-Chou Lin, Yu-Rou Lin
article en

Abstract

This study reveals that CXCL8 drives OSCC metastasis via CXCR1/2-mediated JAK1/STAT3 activation leading to MMP1 transcriptional upregulation. Our findings establish CXCL8 as both a prognostic biomarker and a promising therapeutic target, and suggest that targeting this pathway offers significant therapeutic potential for preventing OSCC metastatic progression.

International Journal of Biological SciencesVol. 22(5)
Asia University (TW), China Medical University (TW), China Medical University Hospital (TW), Wan Fang Hospital (TW), Memorial Hospital (US), Taipei Medical University (TW)
Good health and well-being
Openalex Percentile: Top 55%
Chemokine receptors and signaling
DOIOpen Access PDFOpenAlex
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CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation — Ju-fang Liu, Ying-Sui Sun, et al. · International Journal of Biological Sciences (2026) | TGRS Research Map | TGRS