Compartmentalized VEGF receptor expression in hypothalamic tanycytes reveals a novel non-endothelial axis of VEGF signaling
Our findings unveil, for the first time a non-endothelial VEGF signaling system in hypothalamic tanycytes that is spatially compartmentalized, developmentally programmed and age-dependent. These insights reveal new roles for VEGF signaling in neurovascular and neuroendocrine function, raising important considerations for central effects of VEGF-targeted therapies in aging and disease.
Authors
- Daniela Fernandois (ORCID: https://orcid.org/0000-0002-8282-0189)
- V. Prevot
- Sreekala S. Nampoothiri (ORCID: https://orcid.org/0000-0001-9880-0636)
- Manon Leclerc (ORCID: https://orcid.org/0009-0009-5958-6599)
- Ombeline Desruelle
- Ines Martinez-Corral
- Markus Schwaninger
Institutions
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- European Genomic Institute for Diabetes (FR)
- University of Lübeck (DE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s12987-026-00774-w
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00